In Vitro Metabolism of Irosustat, a Novel Steroid Sulphatase Inhibitor: Inter-Species Comparison, Metabolite Identification and Metabolic Enzyme Identification
نویسندگان
چکیده
238 / 250 Introduction: 453 / 750 Discussion: 1478 / 1500 Nonstandard abbreviations used are: Clint,app apparent intrinsic clearance; CYP, cytochrome P450; FMO, flavin-containing monooxygenase; HLM, human liver microsomes; HPLC, highperformance liquid chromatography; KM, Michaelis Menten constant; LC-MS, liquid chromatography mass spectrometry; MS, mass spectrometry; NMR, nuclear magnetic resonance spectroscopy; SPE, solid phase extraction; STS, steroid sulphatase; SULT, sulfotransferase; UGT, UDP glucuronosyltransferase. DMD #38315 This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on April 4, 2011 as DOI: 10.1124/dmd.111.038315 at A PE T Jornals on O cber 9, 2017 dm d.aspurnals.org D ow nladed from
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In vitro metabolism of irosustat, a novel steroid sulfatase inhibitor: interspecies comparison, metabolite identification, and metabolic enzyme identification.
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